Circadian gene expression in adolescents: Associations with concurrent circadian disruption and subsequent changes in cardiometabolic risk measures

Key Points

• Cardiometabolic risk factors show significant changes related to circadian gene expression among adolescents and sex-specific differences.
• Circadian disruption may influence biological mechanisms that affect health outcomes, particularly in developing adolescents.
• Analysis reveals associations between core clock gene expression and subsequent changes in cardiometabolic measures.
• Findings underscore the importance of understanding circadian biology in addressing adolescent health risks.