An immunomodulatory ochratoxin analogue from marine Aspergillus sp. potentiates macrophage defense against Edwardsiella tarda via AIFM1-mediated necroptosis inhibition

Key Points

• Enhanced macrophage defense is linked to AIFM1-mediated necroptosis inhibition, boosting immune response.
• The ochratoxin analogue exhibits immunomodulatory properties, increasing effectiveness against bacterial infection.
• Observational analysis of marine Aspergillus sp. identifies mechanisms for macrophage defense activation.
• This work highlights potential new therapies for infections caused by Edwardsiella tarda and similar pathogens.