White Matter Microstructural Alterations Mediate the Association between Polygenic Risk for Alzheimer’s Disease and Cognitive Performance in Clinically Asymptomatic Adults

Key Points

• Cognitive performance is influenced by microstructural alterations in white matter, revealing significant implications for Alzheimer’s disease risk.
• Adults with higher polygenic risk for Alzheimer's show more noticeable white matter changes, which correlate with subtle cognitive differences.
• Analysis of the relationship between polygenic risk and cognitive metrics utilized advanced imaging to assess white matter integrity.
• The findings suggest that early detection of cognitive changes linked to microstructural alterations may enable better Alzheimer’s disease management.