Aromaticity-driven laser photo-responses and binding efficiency in IAF-conjugated natural products for neurodegenerative disease targets

Key Points

• Binding efficiency improves significantly with increased aromaticity in IAF-conjugated compounds, indicating potential for drug design.
• Photo-responses of the compounds are influenced by molecular structure, particularly the presence of aromatic rings.
• Assessment across multiple natural products shows promising results for neurodegenerative disease applications, providing insights into mechanism of action.
• The findings suggest a novel approach for targeting neurodegenerative diseases, ranging from Alzheimer's to Parkinson's, using innovative compound modifications.