Front Cover: Enantioselective α‐Aminoxylation of Ketones Catalyzed by a Chiral Brønsted Acid (Adv. Synth. Catal. 3/2026)

Key Points

• The enantioselective α-aminoxylation led to the formation of enantioenriched products, enhancing synthesis efficiency.
• An optimal chiral phosphoric acid catalyst, based on octahydrobinaphthol, facilitated the reaction more effectively than bulkier alternatives.
• Catalysis processes were enriched by controlling the reaction components through an 'enantioselective gate', improving product quality.
• This method highlights the potential of simple catalysts in producing valuable chiral compounds with high enantioselectivity.