Distinct plasma metabolic signature and potential biomarkers in female sigmoid Colon Cancer: A mass spectrometry-based untargeted metabolomics study

Key Points

• Unique plasma metabolic signatures reflect alterations in metabolic pathways involved in cancer progression, revealing potential biomarkers.
• A significant difference in metabolic profiles was observed between healthy controls and those with sigmoid colon cancer, indicating diagnostic potential.
• Mass spectrometry-based untargeted metabolomics was employed to analyze plasma samples, detecting various metabolites linked to cancer.
• Findings highlight the need for further clinical validation and exploration of these plasma biomarkers in broader populations.