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March 3, 2026
ADAM8 negatively regulates the osteogenic differentiation of rat tendon stem cells through inhibiting the PI3K/AKT signaling pathway
WJ
Weiyu Jiang
Baylor College of Medicine
ZZ
Zhang Zhehua
YL
Yan Liu
Key Points
Osteogenic differentiation is diminished when ADAM8 is present, supporting a critical regulatory role.
The PI3K/AKT signaling pathway shows significant inhibition due to ADAM8 activity.
Analysis of rat tendon stem cells provides insight into stem cell regulation mechanisms.
Findings suggest potential therapeutic targets for enhancing tissue regeneration.
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ADAM8 negatively regulates the osteogenic differentiation of rat tendon stem cells through inhibiting the PI3K/AKT signaling pathway | Synapse
Cite This Study
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Jiang et al. (Fri,) studied this question.
synapsesocial.com/papers/69a76893badf0bb9e87e52d3
https://doi.org/https://doi.org/10.1016/j.yexcr.2026.114924