U07, a novel oridonin derivative, targets polo-like kinase 4 (PLK4) to induce ferroptosis in gastric cancer cells

Key Points

• Ferroptosis was induced in gastric cancer cells by targeting polo-like kinase 4 with U07, a novel oridonin derivative.
• The study shows that U07 significantly reduced cell proliferation in cultured gastric cancer cells by 50% in vitro.
• Assessment using molecular pathway analysis demonstrated that U07 effectively inhibits PLK4, leading to enhanced ferroptosis in these cells.
• These findings highlight the potential of U07 in cancer therapy, warranting further exploration of its therapeutic efficacy.