Drug repurposing reveals Fmoc-l-leucine as an adipose thermogenesis activator in cold-exposed mice by targeting PPARγ/UCP1

Key Points

• Adipose thermogenesis was significantly activated following the administration of Fmoc-l-leucine.
• Increased levels of PPARγ and UCP1 were observed, indicating targeted molecular pathways.
• Drug repurposing was used to identify Fmoc-l-leucine as an effective treatment option.
• Findings suggest potential new therapies for obesity management through thermogenesis enhancement.