Multi-brain network functional connectivity in major depressive disorder: a fMRI systematic review of mechanisms and clinical translation

Key Points

• Functional connectivity in major depressive disorder highlights key neural interactions across brain networks, suggesting potential targets for therapy.
• Analysis of findings from multiple fMRI studies reveals significant disruptions in brain communication related to depressive symptoms.
• Systematic review assesses various network mechanisms involved in major depressive disorder that may guide future clinical applications.
• Identifying altered brain networks supports the need for personalized interventions and highlights gaps in understanding depressive disorders.