Oxaloacetate Restores HIF-1α-Mediated Mitochondrial Homeostasis to Counter Tubulointerstitial Injury in Diabetic Kidney Disease.

Key Points

• The aim is to explore how oxaloacetate affects mitochondrial function in renal injury due to diabetic kidney disease.
• Evaluated the impact of oxaloacetate on renal injury in diabetic models
• Assessed mitochondrial homeostasis through the PHD2/HIF-1α axis
• Oxaloacetate significantly improved mitochondrial homeostasis
• Demonstrated a reduction in tubulointerstitial injury markers in diabetic kidney disease