Efficacy of Low-Dose Oral Isotretinoin Combined With Fractional Microneedle Radiofrequency Versus Low-Dose Oral Isotretinoin Monotherapy in the Treatment of Moderate-To-Severe Acne Vulgaris: A Randomized Controlled Comparative Study. | Synapse
March 7, 2026
Efficacy of Low-Dose Oral Isotretinoin Combined With Fractional Microneedle Radiofrequency Versus Low-Dose Oral Isotretinoin Monotherapy in the Treatment of Moderate-To-Severe Acne Vulgaris: A Randomized Controlled Comparative Study.
Key Points
The study aims to compare the efficacy of low-dose oral isotretinoin combined with fractional microneedle radiofrequency versus isotretinoin alone in treating moderate-to-severe acne vulgaris.
Conducted a randomized controlled trial.
Included participants with moderate-to-severe acne vulgaris.
Administered low-dose oral isotretinoin to all participants.
Combined treatment group received fractional microneedle radiofrequency.
Analyzed treatment outcomes using standardized acne severity scales.
The combination treatment showed greater improvements in acne severity scores compared to monotherapy.
Participants receiving the combination therapy reported quicker resolution of lesions.
Adverse events were comparable between both groups, indicating safety.