Our results highlight species-specific differences in ZIKV susceptibility across bat-derived cell lines, with both ZIKV strains replicating to high titers on R. aegyptiacus cells but not on A. jamaicensis cells. We detected pro-inflammatory transcriptomic signatures in R. aegyptiacus cells infected with both ZIKV lineages. Notably, both the Asian-American and African ZIKV lineages demonstrated some capacity for immune evasion and productive replication in the R. aegyptiacus cell line.
Brown et al. (Fri,) studied this question.