What question did this study set out to answer?

To investigate the effects of ShenQi DiHuang Decoction on neuroinflammation and neuropsychiatric symptoms in lupus mice.

March 10, 2026CNS Neuroscience & Therapeutics0 citationsOpen Access

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ShenQi DiHuang Decoction (SQDHD) Ameliorates Neuroinflammation and Neuropsychiatric Manifestations in Pristane Induced Lupus Mice via Blocking JAK1‐STAT3 Pathway

JCJie ChenChina Medical University CCChumiao CuiChina Medical University FXFei XuDalian Municipal Central Hospital

Key Points

To investigate the effects of ShenQi DiHuang Decoction on neuroinflammation and neuropsychiatric symptoms in lupus mice.
Utilized pristane-induced lupus mice model
Administered ShenQi DiHuang Decoction
Assessed neuroinflammation and behavioral changes
Examined JAK1-STAT3 pathway activation
SQDHD reduced neuroinflammation markers in the brain
Improved neuropsychiatric symptoms in treated mice
Blocked activation of the JAK1-STAT3 signaling pathway

Abstract

SQDHD may exert neuroprotective effects in NPSLE by inhibiting the activation of CVECs through blocking the JAK1-STAT3 signaling pathway, thereby suggesting its potential as a promising therapeutic strategy for NPSLE.

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View Full Paper

ShenQi DiHuang Decoction (SQDHD) Ameliorates Neuroinflammation and Neuropsychiatric Manifestations in Pristane Induced Lupus Mice via Blocking JAK1‐STAT3 Pathway

Key Points

Abstract

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