Intraoperative 40 Hz Visual Light Flicker Attenuates Anesthesia/Surgery‐Induced Cognitive Impairments in Elderly Mice With Enhanced Cortical‐Hippocampal Coherence

Key Points

• The research aims to investigate the effects of 40 Hz visual flicker on cognitive impairments caused by anesthesia and surgery in elderly mice.
• Utilized a mouse model of anesthesia and surgery.
• Applied 40 Hz light flicker during the surgical procedure.
• Measured cognitive performance and cortical-hippocampal coherence post-surgery.
• 40 Hz flicker significantly improved cognitive function compared to controls.
• Enhanced gamma coherence between the visual cortex and hippocampus was observed.
• Indications suggest this intervention helps in preventing post-operative cognitive decline (PND).