Effects of nucleation on solvate and polymorph control – evaporative crystallization of taltirelin

Key Points

• The research aims to explore how nucleation influences the solvate and polymorph forms of taltirelin during crystallization.
• Obtained hydrated α- and β-forms from aqueous solvents
• Identified the anhydrous γ-form from organic solvents
• Developed a dimensionless plotting method for polymorph screening
• Successfully obtained different hydrate forms of taltirelin
• First identification of the γ-form
• The dimensionless plotting method shows promise for effective polymorph screening