Methylophiopogonanone a attenuates pulmonary fibrosis by inhibiting SPP1 ‐mediated macrophage polarization via the PI3K /Akt pathway

Key Points

• The research aims to explore the effects of methylophiopogonanone A on pulmonary fibrosis through its involvement in macrophage polarization and associated pathways.
• Identified the effects of methylophiopogonanone A on pulmonary fibrosis.
• Analyzed the role of SPP1 in macrophage polarization.
• Examined the PI3K/Akt signaling pathway's involvement.
• Methylophiopogonanone A significantly reduced pulmonary fibrosis.
• Inhibition of SPP1 led to decreased macrophage polarization.
• Activation of the PI3K/Akt pathway was linked to these effects.