Quercetin prevents age-related hearing loss in C57BL/6J mice by activating mitophagy and inhibiting the NLRP3 inflammasome

Key Points

• The study investigates the effects of quercetin on age-related hearing loss (ARHL) in mice, focusing on its mechanisms.
• Examined the impact of quercetin on C57BL/6J mice experiencing ARHL.
• Assessed the activation of the NLRP3 inflammasome and mitophagy levels post-treatment with quercetin.
• Analyzed changes in auditory function linked to quercetin administration.
• Quercetin administration reduced the activation of the NLRP3 inflammasome in aged mice.
• Activation of mitophagy was increased in mice treated with quercetin.
• These interventions correlated with improved auditory function and protection against ARHL.