What question did this study set out to answer?

Evaluate long-term outcomes of a risk-adapted strategy for managing stage I testicular germ cell tumors while limiting chemotherapy.

March 12, 2026Open Access

23MO Risk-adapted management in stage I testicular germ cell tumors: long-term outcomes from a single-center cohort (1994–2023)

Key Points

Evaluate long-term outcomes of a risk-adapted strategy for managing stage I testicular germ cell tumors while limiting chemotherapy.
Retrospective analysis of a single-center cohort from 1994 to 2023.
Post-orchiectomy management followed a risk-adapted protocol.
Endpoints included relapse, progression-free survival (PFS), overall survival (OS), and cancer-specific survival (CSS).
Associations analyzed using Cox and Fisher's exact tests.
The Boormans three-factor model assessed for surveillance-managed seminoma.
Near-universal cure rates were maintained in the cohorts.
Reduced exposure to chemotherapy in low-risk patients was noted.
Progression-free survival and overall survival rates were comparable to historical data.
The Boormans model demonstrated effective discrimination and calibration for outcomes.

Abstract

Background: Clinical stage I (CSI) testicular germ-cell tumours (TGCT) represent a model of highly curable solid malignancy and the key challenge is now to preserve near-universal cure rates while limiting exposure to potentially toxic adjuvant therapy and long-term sequelae.We evaluated long-term outcomes of a risk-adapted strategy designed to limit chemotherapy to clearly defined high-risk subgroups and to prevent overtreatment in low-risk patients.Methods: Retrospective single-centre cohort of CSI TGCT managed between 1994-2023.Post-orchiectomy management followed a risk-adapted policy.Endpoints were relapse, progression-free survival (PFS), overall survival (OS) and CSS.Associations were analysed with Cox and Fisher's exact tests.In surveillance-managed seminoma, the Boormans three-factor model (categorical size, RTI, LVI) was assessed for discrimination and 5-year calibration.

Demander à l'IA

Bookmark

View Full Paper