What question did this study set out to answer?

This research investigates the role of lactate in altering the function of tumor-associated macrophages (TAMs) in oral squamous cell carcinoma (OSCC).

March 12, 2026

Lactate-induced metabolic reprogramming of TAMs impairs antigen presentation capacity via C/EBPα-CD74 axis in oral squamous cell carcinoma.

Key Points

This research investigates the role of lactate in altering the function of tumor-associated macrophages (TAMs) in oral squamous cell carcinoma (OSCC).
Analyzed CD74 expression in TAMs during OSCC progression.
Examined the effect of tumor-derived lactate on C/EBPα acetylation.
Assessed how loss of CD74 affects antigen presentation and T cell activation.
CD74<sup>hi</sup> TAMs decrease in OSCC, correlating with poor prognosis.
Lactate inhibits CD74 transcription through C/EBPα acetylation.
Reduced CD74 expression leads to impaired antigen presentation and T cell activation.

Abstract

CD74hi TAMs decrease during OSCCprogression and are associated with patient prognosis. Loss of CD74 impairs antigen presentation andsuppresses T cell activation. Tumor-derived lactateinhibits CD74 transcription via C/EBPα acetylation.

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