Inflammatory Gene Expression, Insulin Resistance, and Circulating Markers Vary by Visceral Adiposity in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease.

Key Points

• This research aims to explore how different levels of visceral adiposity affect inflammatory gene expression and insulin resistance in metabolic dysfunction-associated liver disease.
• Analyzed gene expression related to inflammation.
• Assessed insulin resistance in relation to visceral fat levels.
• Evaluated circulating markers indicative of metabolic dysfunction.
• Differential immune changes were observed across varying levels of visceral adiposity.
• Insulin resistance correlated with specific inflammatory markers linked to adiposity profiles.

Abstract