What question did this study set out to answer?

This research aims to evaluate the effectiveness and safety of second-generation antipsychotics in treating children and adolescents with schizophrenia-spectrum disorders.

March 12, 2026

Antipsychotics in Children and Adolescents with Schizophrenia-Spectrum Disorders: A Systematic Review, Meta-Analysis, and Long-Term Prospective Evidence.

Key Points

This research aims to evaluate the effectiveness and safety of second-generation antipsychotics in treating children and adolescents with schizophrenia-spectrum disorders.
Conducted a systematic review and meta-analysis of existing studies
Focused on short-term symptom reduction and side effect profiles
Analyzed evidence for long-term treatment and maintenance
SGAs showed short-term symptom reductions compared to placebo
There was variability in the risk of treatment-emergent adverse events across different agents
Limited long-term evidence necessitates further studies on continuation strategies

Abstract

Several SGAs produce short-term symptom reductions versus placebo in children and adolescents with schizophrenia-spectrum disorders, with heterogeneity in TEAE risk across agents. Evidence for long-term maintenance and continuation remains limited, underscoring the need for adequately powered randomized continuation trials to guide sustained treatment in this population.

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Cite This Study

Vázquez et al. (Tue,) studied this question.

synapsesocial.com/papers/69b25be596eeacc4fceca4b2 https://doi.org/https://doi.org/10.1177/10445463261426993

Discussion

Institutions

Queen's University

McLean Hospital

Kingston General Hospital

References and Citations

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