Aortic valve calcification is a dynamic process that can be modified therapeutically even in advanced disease, though reducing calcium alone may not restore valve function.
Molecular processes that contribute to valvular calcification and osteogenesis remain remarkably labile during the end stages of aortic valve stenosis. Although reductions in valvular calcium deposition were not sufficient to improve valvular function in the animals studied, these findings demonstrate that aortic valve calcification is a remarkably dynamic process that can be modified therapeutically, even in the presence of advanced aortic valve disease.
Miller et al. (Fri,) studied this question.
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