Ring-opening decarbonylative C(sp 3 )–C(sp 3 ) cross-electrophile coupling of cyclic imides with unactivated alkyl chlorides

Key Points

• This research aims to explore the potential of cyclic imides in decarbonylative C(sp3)–C(sp3) cross-electrophile coupling.
• Utilized nickel-mediated activation for N–C(O) bonds
• Engaged cyclic imides as electrophiles
• Combined with unactivated alkyl chlorides for coupling reactions
• Successfully demonstrated C(sp3)–C(sp3) cross-electrophile coupling
• Proved cyclic imides can act as effective electrophiles
• Established a method for coupling using unactivated alkyl chlorides