Synthesis of Ananikov-Type N-Heterocyclic Carbene Golden Synthons as Ferroptosis Inducing Anticancer Agents

Key Points

• The study aims to design and evaluate a new family of metal-based anticancer agents focusing on their mechanism of inducing ferroptosis.
• Synthesis of n-heterocyclic carbene gold compounds
• Evaluation of agents' ability to induce ferroptosis
• Analysis of ligand design and structure-activity relationship
• Newly synthesized agents effectively induce ferroptosis in cancer cells
• Ligand design significantly impacts the potency of these compounds
• Findings support the potential for further development in cancer therapy