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Inflammatory profile of diabetic ketoacidosis in children with type 1 diabetes | Synapse

March 13, 2026Open Access

Inflammatory profile of diabetic ketoacidosis in children with type 1 diabetes

Key Points

To examine the inflammatory changes specific to diabetic ketoacidosis (DKA) in children with type 1 diabetes (T1D).
Analyzed inflammatory profiles in children experiencing DKA
Compared changes in matrix metalloproteinases (MMPs) and their tissue inhibitors to other conditions
Evaluated differences between acute hyperglycemia and T1D autoimmunity
Identified a distinct inflammatory pattern in DKA compared to acute hyperglycemia
Noted significant alterations in levels of MMPs and their inhibitors
Demonstrated that these changes are unique to DKA in type 1 diabetes

Abstract

DKA causes a unique inflammatory pattern distinct from inflammatory changes in acute hyperglycemia or T1D-related autoimmunity. Alterations in MMPs and their tissue inhibitors play a dominant role in this inflammatory profile.

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Cite This Study

Chaffin et al. (Thu,) studied this question.

synapsesocial.com/papers/69b3ac4d02a1e69014ccdd42 https://doi.org/https://doi.org/10.1136/bmjdrc-2025-004961