CFTR Modulators in Brazil: Not for Everyone—A Comparison of Ineligibility Across Different Regions

Key Points

• This research aims to examine the ineligibility rates for CFTR modulators in Brazil and the impact of genetic diversity.
• Analyzed ineligibility rates across various regions in Brazil
• Compared ineligibility among different health centers
• Considered genotypic variations and ancestry within the Brazilian population
• High ineligibility rates for ETI (elexacaftor/tezacaftor/ivacaftor) were observed across all regions
• No significant differences in ineligibility rates among centers
• The study emphasizes the need for health policies to address genetic diversity