AMP-activated protein kinase as a therapeutic target: effects of nano-selenium and thymoquinone in Alzheimer’s disease

Key Points

• The research explores the role of AMPK as a therapeutic target in Alzheimer's disease, focusing on the effects of nano-selenium and thymoquinone.
• Investigated the enhancement of AMPK expression in Alzheimer’s disease models
• Administered nano-selenium and thymoquinone to test their effects
• Analyzed changes in gene expression and potential mechanisms involved
• Thymoquinone significantly enhanced AMPK gene expression
• nano-selenium contributed to the activation of AMPK pathways
• Suggests both compounds may serve as therapeutic agents in Alzheimer's disease