Objective: This review aims to critically evaluate lipidic nanocarriers (liposomes) as effective and targeted delivery systems in cosmeceuticals, with an emphasis on their therapeutic efficacy in dermatological and cosmetic applications. Background: This review aims to critically evaluate lipidic nanocarriers (liposomes) as effective and targeted delivery systems in cosmeceuticals, with an emphasis on their therapeutic efficacy in dermatological and cosmetic applications. Methodology: An extensive literature review was conducted using PubMed/Medline/PMC, Scopus, ScienceDirect, Google Scholar, Google Patents, and ClinicalTrials.gov.in databases. The selected studies focused on L-Omes design, preparation methods, characterization parameters, skin penetration potential, and in vitro/in vivo efficacy within the time 1 May 2015-1 May 2025 (10 years). Recently, commercial cosmeceutical products incorporating L-Omes, along with their clinical trial data and patent developments, have also been highlighted. Results: L-Omes significantly improve the delivery of active agents in cosmeceutical formulations, enhancing skin absorption, prolonging retention, and minimizing systemic toxicity. Vitamins, peptides, antioxidants, and herbal extracts encapsulated with L-Omes showed superior therapeutic efficacy in treating hyperpigmentation, wrinkles, dryness, and acne. Conclusion: L-Omes represent a revolutionary step in the cosmeceutical industry due to their exceptional targeting potential, safety profile, and controlled release properties. L-Omes are ideal carriers for advanced dermatological and cosmetic therapies due to their ability to encapsulate diverse bioactives. Ongoing L-Omes nanotechnology innovations hold promise for personalized and more effective skincare solutions.
Kumar et al. (Tue,) studied this question.