What question did this study set out to answer?

To evaluate the outcomes of radiation-associated sarcoma in a tertiary care center in a resource-constrained setting.

March 14, 2026JCO Global Oncology0 citationsOpen Access

Radiation-Associated Sarcoma in a Resource-Constrained Setting: A Decade of Real-World Outcomes From a Tertiary Care Sarcoma Center in India

VSVarun SheoranAll India Institute of Medical Sciences SSSorun ShishakMedanta The Medicity KSKinjal SinghDR. B.R.A. Institute Rotary Cancer Hospital

Key Points

To evaluate the outcomes of radiation-associated sarcoma in a tertiary care center in a resource-constrained setting.
Assessment of nonmetastatic cases receiving curative surgery
Review of systemic therapies employed
Analysis of survival outcomes over a decade
Most nonmetastatic cases were treated with successful curative surgery
Favorable survival outcomes reported
Limited responses to immunotherapy observed, prompting a need for further research on treatment resistance

Abstract

Despite large, high-grade, and advanced tumors, curative surgery was feasible in most nonmetastatic cases, and systemic therapies were widely used. The favorable survival outcomes underscore the importance of centralized, multidisciplinary sarcoma care in LMICs. Lack of immunotherapy responses calls for investigation into resistance mechanisms and histology-specific treatments.

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