Discontinuation of Heart Failure Pharmacotherapy in Older Adults With Frailty | Synapse
March 15, 2026Open Access
Discontinuation of Heart Failure Pharmacotherapy in Older Adults With Frailty
Key Points
To examine the rates of pharmacotherapy discontinuation in older adults with heart failure and frailty.
Examined older adults diagnosed with heart failure
Assessed discontinuation rates of GDMT over 12 months
Focus on the incidence among those with frailty
Approximately one-third discontinued GDMT within 12 months
Discontinuation rates were higher in older adults with frailty
Abstract
In older adults with heart failure, approximately one-third discontinued GDMT within 12 months, and discontinuation appeared disproportionately common among those with frailty.