What question did this study set out to answer?

To investigate the relationship between plasma biomarkers of neurodegeneration and various mortality risks.

March 16, 2026Neurology0 citations

Circulating Biomarkers of Neurodegeneration and All-Cause and Dementia-Specific Mortality

RSRussell P. Sawyer JBJessica Blair SJSuzanne E. Judd

Key Points

To investigate the relationship between plasma biomarkers of neurodegeneration and various mortality risks.
Analyzed plasma samples for biomarkers GFAP and NfL
Studied a biracial cohort
Assessed mortality outcomes related to all-cause, dementia-specific, and cardiovascular-specific mortality.
Elevated GFAP and NfL levels are associated with increased all-cause mortality risk.
Significant links were found between these biomarkers and dementia-specific mortality.
Cardiovascular-specific mortality also showed associations with neurodegeneration biomarkers.

Abstract

Plasma biomarkers of neurodegeneration, particularly GFAP and NfL, were associated with increased risk of all-cause, dementia-specific, and cardiovascular-specific mortality in a biracial cohort. These associations should be considered when assessing links between these biomarkers and other outcomes, as well as when used in clinical practice.

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