Successful early use of mepolizumab in eosinophilic granulomatosis with polyangiitis presenting with peripheral neuropathy and gastrointestinal bleeding

Key Points

• To evaluate the early use of mepolizumab for treating severe eosinophilic granulomatosis with polyangiitis, particularly focusing on peripheral neuropathy and gastrointestinal symptoms.
• Analyzed a 55-year-old male with eosinophilic granulomatosis and severe symptoms.
• Administered corticosteroid pulse and immunoglobulin therapy initially, followed by mepolizumab.
• Conducted blood tests and capsule endoscopy to assess eosinophil levels and gastrointestinal findings.
• Mepolizumab significantly alleviated gastrointestinal bleeding and peripheral neuropathy symptoms.
• Blood eosinophil counts normalized after mepolizumab treatment.
• Endoscopic examination revealed multiple ulcers, but tissue eosinophil activity was reduced, with no vascular inflammation.