What question did this study set out to answer?

To explore the clinical features and implications of acute myeloid leukemia associated with thrombocytosis.

March 16, 2026Open Access

Acute myeloid leukemia with thrombocytosis: A paradox explained

Key Points

To explore the clinical features and implications of acute myeloid leukemia associated with thrombocytosis.
Case report of a 46-year-old male with documented thrombocytosis and acute myeloid leukemia.
Diagnostic testing for genetic abnormalities, specifically t(3;3)(q23;q23) and MECOM rearrangement.
Monitoring of disease progression and response to induction chemotherapy.
The patient exhibited aggressive disease progression despite chemotherapy.
Thrombocytosis was present, highlighting a rare presentation of acute myeloid leukemia.
The case underscores the need for heightened awareness of the prognostic implications of thrombocytosis in AML.

Abstract

Abstract: Acute myeloid leukemia (AML) with thrombocytosis is a rare entity, accounting for approximately 1% of AML cases. A 46-year-old male presented with fever and thrombocytosis, and was ultimately diagnosed with AML characterized by the recurrent genetic abnormality t(3;3)(q23;q23), associated with MECOM (EVI1) rearrangement. Despite induction chemotherapy, the disease course was aggressive with short-lived remissions and rapid progression. This case highlights the diagnostic challenges, prognostic implications, and therapeutic considerations of this rare AML subtype.

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