What question did this study set out to answer?

The aim is to investigate the emergence and characteristics of the H4N6 avian influenza virus isolated from migratory birds.

March 16, 2026Open Access

Emergence of a novel H4N6 avian influenza virus with mammalian adaptation isolated from migratory birds in Zhejiang Province, China, 2024

Key Points

The aim is to investigate the emergence and characteristics of the H4N6 avian influenza virus isolated from migratory birds.
Isolation of H4N6/G030 strain from a red-necked stint
Analysis of virus receptor binding properties
Assessment of virus replication in avian and mammalian cells
Seroprevalence monitoring in nearby poultry farms
H4N6/G030 can bind avian and mammalian-type sialic acid receptors
The virus replicates effectively in both avian and mammalian cells
High seroprevalence of H4N6 observed in surveyed poultry farms nearby

Abstract

• The H4N6/G030 strain, a novel H4N6 avian influenza virus (AIV), was isolated from a red-necked stint. • The H4N6/G030 is a novel cross-species reassortant derived from wild bird and poultry AIV lineages. • The H4N6/G030 can bind to both avian and mammalian-type sialic acid receptors, and replicate in both avian and mammalian cells and cause disease in animals. • High seroprevalence of H4N6 was observed on surveyed poultry farms nearby.

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Cite This Study

Yang et al. (Sun,) studied this question.

synapsesocial.com/papers/69b79e6e8166e15b153abca2 https://doi.org/https://doi.org/10.1016/j.virs.2026.03.005

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