What question did this study set out to answer?

The study investigates how preoperative heparinization affects postoperative platelet count and ACT levels in open-heart surgery patients.

March 16, 2026

Retrospective study: the effect of preoperative heparinization on postoperative platelet count assessed by ACT levels in open-heart surgery

Key Points

The study investigates how preoperative heparinization affects postoperative platelet count and ACT levels in open-heart surgery patients.
Retrospective analysis of pre- and postoperative hematological and coagulation data.
Grouping patients based on activated clotting time (ACT) and hematocrit (HCT) levels.
Use of parametric and non-parametric tests to assess intergroup differences.
Receiver operating characteristic (ROC) analysis and logistic regression for predictive evaluation.
No significant differences found in most hematological and coagulation parameters based on ACT and HCT levels.
Only PRE.RDW and POST.PLT showed significant differences according to HCT levels.
POST.CRP was the only parameter that was significant according to ACT levels.

Abstract

Aims: Our study aimed to investigate the effect of activated clotting time (ACT) and hematocrit (HCT) levels on commonly used hematological and coagulation parameters (RDW, PLT, MPW, PT, INR, APTT, CRP) in patients undergoing cardiopulmonary bypass (CPB), and to determine the predictive power of these parameters for ACT.Methods: Pre-and postoperative hematological and coagulation data of patients who underwent open-heart surgery with CPB between January 2024 and June 2025 were retrospectively analyzed. Patients were grouped according to ACT and HCT levels. Intergroup differences were assessed using appropriate parametric or non-parametric tests. Receiver operating characteristic (ROC) analysis and logistic regression were performed to evaluate the predictive value of ACT.Results: No significant differences were observed in most hematological and coagulation parameters according to ACT and HCT levels (p0.05). Only PRE.RDW and POST.PLT were significantly different according to HCT levels, and only POST.CRP was significant according to ACT levels (p

Bookmark

Cite This Study

ERSÖZ et al. (Tue,) studied this question.

synapsesocial.com/papers/69b79e6e8166e15b153abcc5 https://doi.org/https://doi.org/10.38053/acmj.1834922

Bookmark