What question did this study set out to answer?

This research aims to explore the relationship between early apoptosis and orthodontically induced root resorption (OIRR) and evaluate the effects of lithium.

March 18, 2026Open Access

Early apoptosis predicts orthodontically induced root resorption: inhibitory effects of lithium in a rat model

Key Points

This research aims to explore the relationship between early apoptosis and orthodontically induced root resorption (OIRR) and evaluate the effects of lithium.
Utilized a rat model to assess PDL compression and apoptosis levels during orthodontic treatment.
Administered lithium to observe its impact on OIRR and apoptosis rates.
Analyzed the relationship between early apoptosis and the onset of OIRR.
Lithium significantly suppressed early apoptosis in the experimental groups.
No changes in periodontal ligament compression were noted despite lithium treatment.
Early apoptosis was identified as a key factor in predicting OIRR onset.

Abstract

Early PDL compression and apoptosis play pivotal roles in OIRR initiation and are potential predictive markers. Lithium attenuated OIRR by suppressing early apoptosis without altering PDL compression, highlighting early apoptosis as a promising therapeutic target for OIRR prevention.

Early apoptosis predicts orthodontically induced root resorption: inhibitory effects of lithium in a rat model

Key Points

Abstract

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