New insights into susceptibility to major depression in a Colombian population | Synapse
March 18, 2026Open Access
New insights into susceptibility to major depression in a Colombian population
Key Points
The goal is to investigate genetic factors contributing to susceptibility to major depression (MDD) in a Colombian population.
Analysis of specific genetic polymorphisms associated with MDD
Focus on polymorphisms rs796296176, rs779504604, and rs1805005
Assessment of the role of MC1R in MDD susceptibility
Identified polymorphisms significantly increase the risk for MDD
Novel evidence linking MC1R polymorphisms to MDD risk
Abstract
Several of the analyzed polymorphisms (rs796296176, rs779504604, rs1805005) increase the risk for MDD. Notably, we provide novel evidence of these polymorphisms in MC1R as a risk to MDD.