Objectives: This study evaluates the safety and efficacy of Liplase ® treatment in improving lip volume, color, and texture among skin of color patients, with additional outcomes such as patient and physician satisfaction and pain assessment. Material and Methods: A prospective, interventional study was conducted on 15 patients (aged 18–54) with skin of color over 6 months. The treatment utilized Erbium-doped Yttrium Aluminum Garnet (Er:YAG) and Neodymium-doped Yttrium Aluminum Garnet (Nd:YAG) lasers with intraoral and extraoral passes, repeated monthly for three sessions. Baseline and follow-up assessments included 3D imaging, colorimetry, and satisfaction scores. Pain was assessed using the visual analogue scale (VAS). Results: Thirteen patients completed the study. Improvements in lip color, texture, volume, and a decrease in wrinkles were observed, with a reduction in melanin and increased erythema scores in 11 patients. Satisfaction scores revealed 100% improvement in lip color, 76.9% in texture, and 53% in volume. Physician ratings corroborated these findings. Pain scores varied, with most patients reporting mild-to-moderate discomfort. Minimal downtime, characterized by peeling, was managed effectively with moisturizers. The treatment was well-tolerated with manageable downtime. Conclusion: This study underscores Liplase ® as a safe and effective method for lip rejuvenation, particularly in the
Shenoy et al. (Mon,) studied this question.