Mannich reaction with organozinc reagents in continuous flow: experimental and computational studies

Key Points

• To explore the efficiency and dynamics of the Mannich reaction using organozinc reagents in a continuous flow setup.
• Conducted experiments to optimize reaction conditions in continuous flow.
• Utilized computational studies to analyze reaction mechanisms and kinetics.
• Employed organozinc reagents as key reactants in the Mannich reaction.
• Achieved enhanced reaction rates compared to traditional batch processes.
• Demonstrated favorable yields and selectivity in product formation.
• Identified key parameters influencing reaction efficiency.