Comment on “Dithiocarbamate-mediated thioamidation of arylglyoxylic acids by decarboxylative–decarbonylative C–C bond formation reactions” by D. Patra and A. Saha, Org. Chem. Front. , 2023, 10 , 1686

Key Points

• To assess the validity of the proposed mechanism for the thioamidation of arylglyoxylic acids.
• Analysis of reaction yields
• Use of 13C labeling to track carbon
• Computational studies to evaluate the mechanism
• The reaction yields are only 5%, indicating inefficiency.
• The proposed mechanism was shown to be incorrect based on computational analysis.