Abstract Iron nanoparticles have emerged as highly efficient, sustainable, and cost-effective nanocatalysts for quinoline synthesis. In particular, surface functionalized Fe nanoparticles exhibit enhanced catalytic efficacy, improved selectivity, and excellent reusability and thereby demonstrating remarkable potential in the development of quinoline scaffolds. Quinoline is a privileged N-heterocycle and is present in many bioactive and natural products that are beneficial for human beings. This study highlights recent advancements in Fe NPs-catalyzed approaches like Hantzsch reaction, Friedlander synthesis, Aza-ene reaction, condensation reaction and cyclization reaction. These approaches offer mild reaction conditions, high efficiency and improved sustainability, thereby broadening the scope and applicability of quinoline derivatives in pharmaceutical chemistry, materials science, and other domains of science. In this context, Fe NPs catalysis signifies a promising and nature-friendly platform for the sustainable development of structurally varied quinoline derivatives, fostering future advancements in both academic research and industry synthesis. The current review covers the literature from 2020 to 2025 that focuses on Fe NPs-catalyzed strategies towards the development of quinoline based molecular architectures.
Sharma et al. (Thu,) studied this question.