What type of study is this?

This is a Systematic Review study.

What question did this study set out to answer?

This research aims to identify and evaluate modifiable risk factors for Alzheimer's disease in Latin American populations.

March 22, 2026Open Access

Modifiable Risk Factors for Alzheimer's Disease in Latin America: A Systematic Review of Epidemiological Evidence (2000-2024)

Key Points

This research aims to identify and evaluate modifiable risk factors for Alzheimer's disease in Latin American populations.
Conducted a systematic review of 63 studies
Examined 12 risk factors identified by the Lancet Commission
Analyzed population-attributable fractions of 35-48%
Identified low educational attainment as a major risk factor (OR 1.8-3.2)
Highlighted hypertension as another significant risk factor (OR 1.6-2.4)
Established potential for targeted public health interventions

Abstract

Systematic review of modifiable risk factors for Alzheimer's disease in Latin American populations (2000-2024). Analyzes 63 studies examining 12 Lancet Commission risk factors. Combined population-attributable fraction estimates: 35-48%. Low educational attainment (OR 1.8-3.2) and hypertension (OR 1.6-2.4) are the highest-priority targets. Linked dataset: https://doi.org/10.7910/DVN/UVHABW (CC0 1.0)

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