The 2025 WAO Guidelines for the classification, diagnosis, and treatment of hereditary angioedema, with consideration of worldwide disparities

Key Points

• To establish a globally applicable framework for the classification, diagnosis, and treatment of hereditary angioedema (HAE).
• Developed evidence-informed guidelines based on current clinical understanding of HAE.
• Considered worldwide disparities in access to diagnosis and treatment.
• Outlined recommendations for management of HAE, focusing on patient outcomes.
• Defined key aspects of hereditary angioedema including its genetic basis and symptoms.
• Emphasized the role of bradykinin in swelling episodes.
• Provided a comprehensive guideline aiming to improve quality of life for patients worldwide.