What question did this study set out to answer?

This research aims to explore the relationship between central sensitization and opioid use following total knee arthroplasty, focusing on sex differences.

March 23, 2026The Knee1 citationsOpen Access

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Sex matters: central sensitization and opioid use after total knee arthroplasty

JMJ. Purdon MartinVanderbilt University Medical Center RVReece VespermanVanderbilt University Medical Center MDMary S. DietrichVanderbilt University

Key Points

This research aims to explore the relationship between central sensitization and opioid use following total knee arthroplasty, focusing on sex differences.
Analyzed preoperative central sensitization index (CSI) scores in males and females
Measured postoperative opioid consumption levels
Comparative analysis of opioid use against normative data
Males with high preoperative CSI scores maintained higher opioid use post-surgery
Central sensitization served as a significant predictor of opioid consumption
Findings highlight the need for sex-specific pain management approaches

Abstract

Central sensitization significantly impacts opioid use in males post-TKA, challenging existing beliefs. Males with preoperative CSI scores indicating central sensitization showed sustained opioid use above norms, suggesting CSI as a predictive tool for postoperative opioid consumption. Recognizing sex-specific differences in central sensitization could improve pain management and opioid prescribing in TKA.

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Cite This Study

Martin et al. (Fri,) studied this question.

synapsesocial.com/papers/69c0ddb8fddb9876e79c1163 https://doi.org/https://doi.org/10.1016/j.knee.2026.104426

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