What question did this study set out to answer?

This research investigates the clinical features and molecular epidemiology of KPC-NDM co-producing Klebsiella pneumoniae in China.

March 23, 2026Open Access

Clinical characteristics and molecular epidemiology of KPC-NDM co-producing carbapenem-resistant Klebsiella pneumoniae in China: a multicentre retrospective case-control study

Key Points

This research investigates the clinical features and molecular epidemiology of KPC-NDM co-producing Klebsiella pneumoniae in China.
Conducted a multicentre retrospective case-control study
Analyzed clinical and molecular data from various hospitals
Utilized statistical analysis for data interpretation
Identified specific clinical characteristics associated with KPC-NDM co-production
Revealed the prevalence of carbapenem resistance in Klebsiella pneumoniae
Outlined molecular patterns that distinguish strains across different regions

Abstract

National Natural Science Foundation of China (82472323 and 82172306), Zhejiang Province Natural Science Foundation of China (LQN26H200003, LR25H200001, LQN25H200002, MS25H190009), the "Pioneer" and "Leading Goose" R&D Program of Zhejiang Province (2025C02187), the Zhejiang Provincial Medical and Health Technology Project (2025HY0224) and Zhejiang Provincial Disease Prevention and Control Science and Technology Program (2025JK063). We appreciate the statistical support provided by Hui Liu (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China).

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