Does sequential dual-energy RF and PFA ablation terminate incessant VT in a patient with severe ischaemic cardiomyopathy?
Colocalized sequential RF and PFA ablation is a feasible adjunct strategy for terminating incessant VT in suspected intramural post-infarction substrate, though further systematic evaluation is needed.
Abstract Background Incessant ventricular tachycardia (VT) in advanced ischaemic cardiomyopathy is a life-threatening condition, particularly when maintained by deep intramyocardial scar channels that can be difficult to eliminate with conventional radiofrequency (RF) ablation. Pulsed-field ablation (PFA) is a non-thermal, myocardium-selective modality with the potential to target arrhythmogenic tissue while minimising collateral injury. Case Summary We report a case of incessant VT in a 60-year-old man with severe ischaemic cardiomyopathy in whom acute VT termination and final non-inducibility were achieved using a sequential dual-energy strategy combining RF and PFA delivered with a 3.5 mm open-irrigated catheter capable of both modalities (Dual Energy THERMOCOOL SMARTTOUCH™ DE-STSF, Johnson & Johnson MedTech). The procedure was performed under extracorporeal cardiopulmonary resuscitation (eCPR) via veno-arterial extracorporeal membrane oxygenation (VA-ECMO) during electrical storm. Despite VT termination and arrhythmia control, the patient died on day 5 from refractory shock with progressive multiorgan failure. Discussion This case supports the feasibility of colocalised sequential RF–PFA (“energy stacking”) as an adjunct strategy for suspected intramural post-infarction VT substrate in selected high-risk patients. Supported by VA-ECMO, this dual-energy strategy achieved acute VT non-inducibility and arrhythmia control, despite an unfavourable overall clinical outcome. Further systematic evaluation is warranted to define the incremental role of dual-energy lesion delivery in ventricular substrates.
Borlich et al. (Wed,) studied this question.