Correlation between single-nucleotide polymorphisms at the rs3745453 locus of the miR-23a gene and sudden sensorineural hearing loss in the Han population

Key Points

• The aim is to investigate the association between polymorphisms in the miR-23a gene and the risk of sudden sensorineural hearing loss (SSNHL).
• Analyzed single-nucleotide polymorphisms at the rs3745453 locus
• Examined miR-23a gene expression levels
• Evaluated susceptibility to adult-onset SSNHL in the Han population
• miR-23a expression levels could be used as a diagnostic biomarker for SSNHL
• The rs3745453 polymorphism is linked to higher risk of adult-onset SSNHL
• Increased miR-23a expression correlates with susceptibility to SSNHL