Stable focusing of proteins within a packed microbead bed by ion concentration polarization in a paper-based analytical device

Key Points

• This research aims to enhance protein focusing in paper-based analytical devices using ion concentration polarization.
• Developed a microbead bed setup integrated with paper-based device technology.
• Utilized ion concentration polarization to concentrate proteins within the microbead bed.
• Conducted tests to assess the efficiency and stability of protein focusing under varying ion concentrations.
• Achieved stable focusing of proteins within the microbead bed.
• Demonstrated improved sensitivity for protein detection compared to conventional methods.
• Highlighted the potential for practical clinical applications in resource-limited environments.