Molecular and immune landscape of recurrent and/or distant metastatic squamous cell carcinoma of the head and neck: an EORTC/IMMUCAN project | Synapse
March 25, 2026Open Access
Molecular and immune landscape of recurrent and/or distant metastatic squamous cell carcinoma of the head and neck: an EORTC/IMMUCAN project
Key Points
The aim is to examine molecular and immune variations among recurrent and metastatic squamous cell carcinoma subgroups.
Analyzed molecular profiles of different SCCHN subgroups
Identified immune characteristics associated with recurrent disease
Evaluated potential biomarkers for targeted therapies
Highlighted significant molecular differences among R/M SCCHN subgroups
Identified specific immune markers that correlate with prognosis
Proposed biological rationales for personalized treatment approaches
Abstract
Our study highlights key molecular and immune differences across R/M SCCHN subgroups, identifies potential biomarkers, and suggests biological rationales for tailored therapeutic strategies.